Over 5 Years
Since Published

Backtracking Due to Residual Structure in the Unfolded State Changes the Folding of the Third Fibronectin Type Iii Domain from Tenascin-c

Residual structure in the unfolded state of a protein may play a crucial role in folding and stability. In the present study, using an all (heavy)... (more)

Angel Garcia George Makhatadze Angel Garcia and 1 other
Over 5 Years
Since Published

Cavities Determine the Pressure Unfolding of Proteins

It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by press... (more)

Catherine Royer Angel Garcia Catherine Royer and 1 other
Almost 4 Years
Since Published

Complex Pathways in Folding of Protein G Explored by Simulation and Experiment

The B1 domain of protein G has been a classic model system of folding for decades, the subject of numerous experimental and computational studies.... (more)

Vijay Pande Lisa Lapidus Vijay Pande and 1 other
Over 4 Years
Since Published

Denatured State Ensembles with the Same Radii of Gyration Can Form Significant Different Long-range Contacts.

Defining the structural, dynamic, and energetic properties of the unfolded state of proteins is critical for an in-depth understanding of protein ... (more)

Dan Raleigh Rohit Pappu Dan Raleigh and 1 other
Over 5 Years
Since Published

Effect of Internal Cavities on Folding Rates and Routes Revealed by Real-time Pressure-jump Nmr Spectroscopy

The time required to fold proteins usually increases significantly under conditions of high pressure. Taking advantage of this general property of... (more)

Catherine Royer Angel Garcia Catherine Royer and 1 other
Over 5 Years
Since Published

Experiments and Simulations Show How Long-range Contacts Can Form in Expanded Unfolded Proteins with Negligible Secondary Structure

The sizes of unfolded proteins under highly denaturing conditions scale as N(0.59) with chain length. This suggests that denaturing conditions mim... (more)

Rohit Pappu Dan Raleigh Rohit Pappu and 1 other
Over 4 Years
Since Published

Folding of a Large Protein at High Structural Resolution

Kinetic folding of the large two-domain maltose binding protein (MBP; 370 residues) was studied at high structural resolution by an advanced hydro... (more)

Walter Englander Tobin Sosnick Walter Englander and 1 other
Over 5 Years
Since Published

High Pressure Saxs Studies of Folded and Unfolded Ensembles of Proteins

A structural interpretation of the thermodynamic stability of proteins requires an understanding of the structural properties of the unfolded stat... (more)

Catherine Royer Catherine Royer
Over 6 Years
Since Published

Kinetic Consequences of Native State Optimization of Surface-exposed Electrostatic Interactions in the Fyn Sh3 Domain

Optimization of surface exposed charge.charge interactions in the native state has emerged as an effective means to enhance protein stability; but... (more)

Hue-sun Chan George Makhatadze Hue-sun Chan and 1 other
Over 5 Years
Since Published

Modulation of Frustration in Folding by Sequence Permutation

Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rou... (more)

Bob Matthews Charles Brooks Bob Matthews and 1 other

Showing 10 of 29 Publications