Over 4 Years
Since Published

Nonadditive Entropies Yield Probability Distributions with Biases Not Warranted by the Data

Different quantities that go by the name of entropy are used in variational principles to infer probability distributions from limited data. Shore... (more)

Kingshuk Ghosh Kingshuk Ghosh
5 Years
Since Published

Structural Plasticity of Staphylococcal Nuclease Probed by Perturbation by Pressure and Ph

The ionization of internal groups in proteins can trigger conformational change. Despite this being the structural basis of most biological energy... (more)

Catherine Royer Catherine Royer
3 Years
Since Published

Non-native Structure Appears in Microseconds during the Folding of E. Coli Rnase H

The folding pathway of Escherichia coli RNase H is one of the best experimentally characterized for any protein. In spite of this, spectroscopic s... (more)

Susan Marqusee Bob Matthews Osman Bilsel Susan Marqusee and 2 others
5 Years
Since Published

Unique Features of the Folding Landscape of a Repeat Protein Revealed by Pressure Perturbation

The volumetric properties of proteins yield information about the changes in packing and hydration between various states along the folding reacti... (more)

Catherine Royer Doug Barrick Catherine Royer and 1 other
Almost 6 Years
Since Published

Kinetic Consequences of Native State Optimization of Surface-exposed Electrostatic Interactions in the Fyn Sh3 Domain

Optimization of surface exposed charge.charge interactions in the native state has emerged as an effective means to enhance protein stability; but... (more)

Hue-sun Chan George Makhatadze Hue-sun Chan and 1 other
5 Years
Since Published

High Pressure Saxs Studies of Folded and Unfolded Ensembles of Proteins

A structural interpretation of the thermodynamic stability of proteins requires an understanding of the structural properties of the unfolded stat... (more)

Catherine Royer Catherine Royer
Over 4 Years
Since Published

Perspective: Reaches of Chemical Physics in Biology

Chemical physics as a discipline contributes many experimental tools, algorithms, and fundamental theoretical models that can be applied to biolog... (more)

Dave Thirumalai Martin Gruebele Dave Thirumalai and 1 other
5 Years
Since Published

Experiments and Simulations Show How Long-range Contacts Can Form in Expanded Unfolded Proteins with Negligible Secondary Structure

The sizes of unfolded proteins under highly denaturing conditions scale as N(0.59) with chain length. This suggests that denaturing conditions mim... (more)

Rohit Pappu Dan Raleigh Rohit Pappu and 1 other
4 Years
Since Published

Denatured State Ensembles with the Same Radii of Gyration Can Form Significant Different Long-range Contacts.

Defining the structural, dynamic, and energetic properties of the unfolded state of proteins is critical for an in-depth understanding of protein ... (more)

Dan Raleigh Rohit Pappu Dan Raleigh and 1 other
Almost 5 Years
Since Published

Stepwise Protein Folding at near Amino Acid Resolution by Hydrogen Exchange and Mass Spectrometry

The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass s... (more)

Walter Englander Susan Marqusee Walter Englander and 1 other

Showing 10 of 29 Publications