Over 5 Years
Since Published

Probing the Physical Determinants of Thermal Expansion of Folded Proteins

The magnitude and sign of the volume change upon protein unfolding are strongly dependent on temperature. This temperature dependence reflects dif... (more)

Catherine Royer Catherine Royer
Over 5 Years
Since Published

Structural, Energetic and Dynamic Responses of the Native State Ensemble of Staphylococcal Nuclease to Cavity-creating Mutations

The effects of cavity-creating mutations on the structural flexibility, local and global stability, and dynamics of the folded state of staphyloco... (more)

Angel Garcia Catherine Royer Angel Garcia and 1 other
Over 5 Years
Since Published

Cavities Determine the Pressure Unfolding of Proteins

It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by press... (more)

Catherine Royer Angel Garcia Catherine Royer and 1 other
Over 5 Years
Since Published

Structural Plasticity of Staphylococcal Nuclease Probed by Perturbation by Pressure and Ph

The ionization of internal groups in proteins can trigger conformational change. Despite this being the structural basis of most biological energy... (more)

Catherine Royer Catherine Royer
Over 5 Years
Since Published

High Pressure Saxs Studies of Folded and Unfolded Ensembles of Proteins

A structural interpretation of the thermodynamic stability of proteins requires an understanding of the structural properties of the unfolded stat... (more)

Catherine Royer Catherine Royer
Over 5 Years
Since Published

Unique Features of the Folding Landscape of a Repeat Protein Revealed by Pressure Perturbation

The volumetric properties of proteins yield information about the changes in packing and hydration between various states along the folding reacti... (more)

Catherine Royer Doug Barrick Catherine Royer and 1 other
Over 5 Years
Since Published

Modulation of Frustration in Folding by Sequence Permutation

Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rou... (more)

Bob Matthews Charles Brooks Bob Matthews and 1 other
Over 5 Years
Since Published

Remodeling of the Folding Free Energy Landscape of Staphylococcal Nuclease by Cavity-creating Mutations

The folding of staphylococcal nuclease (SNase) is known to proceed via a major intermediate in which the central OB subdomain is folded and the C-... (more)

Catherine Royer Angel Garcia Catherine Royer and 1 other
3 Years
Since Published

Non-native Structure Appears in Microseconds during the Folding of E. Coli Rnase H

The folding pathway of Escherichia coli RNase H is one of the best experimentally characterized for any protein. In spite of this, spectroscopic s... (more)

Susan Marqusee Bob Matthews Osman Bilsel Susan Marqusee and 2 others

Showing 29 of 29 Publications