Over 3 Years
Since Published

Single Molecule Conformational Memory Extraction: P5ab Rna Hairpin

Extracting kinetic models from single molecule data is an important route to mechanistic insight in biophysics, chemistry, and biology. Data colle... (more)

Susan Marqusee Susan Marqusee
Over 3 Years
Since Published

Denatured State Ensembles with the Same Radii of Gyration Can Form Significant Different Long-range Contacts.

Defining the structural, dynamic, and energetic properties of the unfolded state of proteins is critical for an in-depth understanding of protein ... (more)

Dan Raleigh Rohit Pappu Dan Raleigh and 1 other
3 Years
Since Published

Complex Pathways in Folding of Protein G Explored by Simulation and Experiment

The B1 domain of protein G has been a classic model system of folding for decades, the subject of numerous experimental and computational studies.... (more)

Vijay Pande Lisa Lapidus Vijay Pande and 1 other
Almost 3 Years
Since Published

Thermodynamic System Drift in the Evolution of Protein Thermostability

Proteins from thermophiles are generally more thermostable than their mesophilic homologs, but little is known about the evolutionary process driv... (more)

Susan Marqusee Michael Harms Susan Marqusee and 1 other
Almost 3 Years
Since Published

The Nature of Protein Folding Pathways

How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the ... (more)

Walter Englander Walter Englander
Almost 4 Years
Since Published

Folding of a Large Protein at High Structural Resolution

Kinetic folding of the large two-domain maltose binding protein (MBP; 370 residues) was studied at high structural resolution by an advanced hydro... (more)

Walter Englander Tobin Sosnick Walter Englander and 1 other
Over 4 Years
Since Published

The Denatured State Ensemble Contains Significant Local and Long-range Structure under Native Conditions: Analysis of the N-terminal Domain of Ribosomal Protein L9

The denatured state ensemble (DSE) represents the starting state for protein folding and the reference state for protein stability studies. Residu... (more)

Dan Raleigh Rohit Pappu Dan Raleigh and 1 other
Over 4 Years
Since Published

Experiments and Simulations Show How Long-range Contacts Can Form in Expanded Unfolded Proteins with Negligible Secondary Structure

The sizes of unfolded proteins under highly denaturing conditions scale as N(0.59) with chain length. This suggests that denaturing conditions mim... (more)

Rohit Pappu Dan Raleigh Rohit Pappu and 1 other
Over 4 Years
Since Published

Backtracking Due to Residual Structure in the Unfolded State Changes the Folding of the Third Fibronectin Type Iii Domain from Tenascin-c

Residual structure in the unfolded state of a protein may play a crucial role in folding and stability. In the present study, using an all (heavy)... (more)

Angel Garcia George Makhatadze Angel Garcia and 1 other
Almost 5 Years
Since Published

Molecular Mechanism for the Preferential Exclusion of Osmolytes from Protein Surfaces

Trimethylamine N-oxide (TMAO) is a naturally occurring protecting osmolyte that stabilizes the folded state of proteins and also counteracts the d... (more)

Angel Garcia George Makhatadze Angel Garcia and 1 other

Showing 10 of 29 Publications