Over 6 Years
Since Published

Kinetic Consequences of Native State Optimization of Surface-exposed Electrostatic Interactions in the Fyn Sh3 Domain

Optimization of surface exposed charge.charge interactions in the native state has emerged as an effective means to enhance protein stability; but... (more)

Hue-sun Chan George Makhatadze Hue-sun Chan and 1 other
Over 3 Years
Since Published

The Nature of Protein Folding Pathways

How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the ... (more)

Walter Englander Walter Englander
5 Years
Since Published

Stepwise Protein Folding at near Amino Acid Resolution by Hydrogen Exchange and Mass Spectrometry

The kinetic folding of ribonuclease H was studied by hydrogen exchange (HX) pulse labeling with analysis by an advanced fragment separation mass s... (more)

Walter Englander Susan Marqusee Walter Englander and 1 other
Over 4 Years
Since Published

Folding of a Large Protein at High Structural Resolution

Kinetic folding of the large two-domain maltose binding protein (MBP; 370 residues) was studied at high structural resolution by an advanced hydro... (more)

Walter Englander Tobin Sosnick Walter Englander and 1 other
Almost 6 Years
Since Published

Native State Conformational Heterogeneity of Hp35 Revealed by Time-resolved Fret.

The villin headpiece subdomain (HP35) has become one of the most widely used model systems in protein folding studies, due to its small size and u... (more)

Feng Gai Feng Gai
Over 5 Years
Since Published

Backtracking Due to Residual Structure in the Unfolded State Changes the Folding of the Third Fibronectin Type Iii Domain from Tenascin-c

Residual structure in the unfolded state of a protein may play a crucial role in folding and stability. In the present study, using an all (heavy)... (more)

Angel Garcia George Makhatadze Angel Garcia and 1 other
Almost 6 Years
Since Published

Molecular Mechanism for the Preferential Exclusion of Osmolytes from Protein Surfaces

Trimethylamine N-oxide (TMAO) is a naturally occurring protecting osmolyte that stabilizes the folded state of proteins and also counteracts the d... (more)

Angel Garcia George Makhatadze Angel Garcia and 1 other
Over 5 Years
Since Published

Structural, Energetic and Dynamic Responses of the Native State Ensemble of Staphylococcal Nuclease to Cavity-creating Mutations

The effects of cavity-creating mutations on the structural flexibility, local and global stability, and dynamics of the folded state of staphyloco... (more)

Angel Garcia Catherine Royer Angel Garcia and 1 other
Over 4 Years
Since Published

Nonadditive Entropies Yield Probability Distributions with Biases Not Warranted by the Data

Different quantities that go by the name of entropy are used in variational principles to infer probability distributions from limited data. Shore... (more)

Kingshuk Ghosh Kingshuk Ghosh
Over 6 Years
Since Published

Physical Limits of Cells and Proteomes

What are the physical limits to cell behavior? Often, the physical limitations can be dominated by the proteome, the cell's complement of proteins... (more)

Kingshuk Ghosh Kingshuk Ghosh

Showing 10 of 29 Publications